Plenary Speakers
Jürgen Groll
University of Würz-burg
2018/11/25 21:20:41
Chair for Functional Materials in Medicine and Dentistry
University of Würz-burg, Germany
Email: Juergen.groll@fmz.uni-wuerzburg.de
PROFESSIONAL EXPERIENCE
since 08/10
Affiliation : University of Würzburg, Würzburg, Germany
Research interest: Applied polymer chemistry, nanobiotechnology, biomimetic scaffolds, immunomodulatory materials and scaffolds, biofabrication
Function: Full professor (W3) and chair for functional materials in medicine and dentistry (www.fmz.uni-wuerzburg.de)
08/04 – 07/10
Affiliation: DWI at the RWTH Aachen e.V., Aachen, Germany
Function: Group leader: polymer chemistry, biomaterials, nanotechnology
02/05 – 12/08
Affiliation: Sustech GmbH & Co KG, Darmstadt, Germany
Function: Senior Researcher nanotechnology, functional materials and coatings
STUDIES AND EDUCATION
11/00 – 08/04: PhD thesis at the RWTH Aachen (summa cum laude)
Supervisor: Martin M?ller
Title: Specific and Directed Biomolecular Recognition on Star PEG Coatings
10/95 – 10/00 Chemistry studies at the University of Ulm (Diploma excellent)
Major: Macromolecular chemistry, organic chemistry and biochemistry
06/1999 – 12/1999 Research internship with Virgil Percec (University of Pennsylvania
Abstract:
Hydrogel-bioinks: rheological demands and thiol-ene cross-linking for better control over cross-linking density
Biofabrication is a young and dynamically evolving field of research. It aims at the auto-mated generation of hierarchical tissue-like structures from cells and materials through Bi-oprinting or Bioassembly. This approach has the potential to overcome a number of classical challenges relating to organization, personalized shape and mechanical integrity of generated constructs.
Although this has allowed achieving some remarkable successes, it has recently become evident that the lack of variety in printable hydrogel systems is one major drawback for the complete field. In order to be suitable for Biofabrication, hydrogels have to comply with a number of prerequisites with regards to rheological behavior and especially stabilization of the printed structure instantly after printing, while at the same time allowing the cells to proliferate. This contribution will present some of our recent work in this field, starting with a method to assess bioink printability. It will then introduce thiol-ene cross-linking as alternative to the often used free radical polymerization to stabilize printed hydrogel structures with better control over network characteristics. This enables the control over nanoparticle migration in and release from printed hydrogel constructs and can be transferred to gelatin as one of the most widely applied bioink systems.