Kaiming Ye
Kaiming Ye, PhD
Professor
Department Chair of Biomedical Engineering
Director of Center of Biomanufacturing for Regenerative Medicine
Binghamton University (BU), State University of New York (SUNY), United States
Biography:
Dr. Kaiming Ye is Professor and Department Chair of Biomedical Engineering and Director of Center of Biomanufacturing for Regenerative Medicine at the Binghamton University (BU), State University of New York (SUNY). He is one of the top most distinguished and accomplished leaders in the field of Medical and Biological Engineering. He is fellow of AIMBE and senior member of IEEE. His scholarly contributions to the field include the development of the concept of advanced biomanufacturing and his leadership role in promoting and growing the field. He co-organized more than 10 workshops, including two WTEC studies: one for global assessment of stem cell science and engineering and the other for global assessment of advanced biomanufacturing to promote and grow the field of advanced biomanufacturing, He is well known for his work in bioprinting and pancreatic organoid development. He has invented a tissue biofabrication platform tissue organoid development and fluorescent nanosensors for continuous glucose monitoring. His work in advanced biomanufacturing was featured as a cover story of ASEE PRISM journal. His work in glucose sensors was featured in the Pittsburgh Post-Gazette. His research has been continuously supported by NIH, NSF, JDRF, ABI and industries. He has chaired and co-chaired a number of international conferences and has delivered keynote/plenary speech in numerous international and national conferences. He is also a highly accomplished administrator and has contributed significantly to national policy-make in science and engineering. During his tenure at NSF, he directed a biomedical engineering program, making funding decisions and implementing post-award management. He was member of a number of interagency working groups, including the Interagency Workgroup for Neuroscience under the Office of Science and Technology Policy (OSTP), Interagency Modeling and Analysis Workgroup, and Multiagency Tissue Engineering and Regenerative Medicine Workgroup. In addition, he was involved in NSF CIF21 IGRET program, cyber-enabled science and engineering program, NIH/NSF joint program on interface between physics and life science, and NIH/NCI-NSF Physicals and Engineering Sciences in Oncology program. Finally, he is a highly accomplished educator in biomedical engineering. As chair of Biomedical Engineering Department at BU, he led the growth of the Department.
Abstract:
Bioinks for 3D Printing Tissue Engineered Vascular Grafts
3D bioprinting enables developing tissue constructs with heterogeneous compositions and complex structures. It has been adopted for printing multicellular tissues. Bioengineered vascular constructs have gained increased interest as a promising alternative to autologous vessel grafts. 3D printed vascular constructs promise to be a customizable, patient specific alternative but the question of whether to use synthetic or natural materials remains. In this work, we characterized an additive biomanufacturing method that allows the use of a soft biomaterial, fibrinogen, but enhances its printability to be compatible with extrusion bioprinting using a thermosreversible gelatin. With a 3D rotatory bioprinter developed in our lab, we demonstrated the feasibility of on-demand printing tissue engineered vascular grafts. We interrogated a number of biomaterials and developed a blend bioink that possesses essential rheological properties for rotatory bioprinting. We showed that the printed constructs increased in elastic modulus and ultimate tensile strength over time with viable cells observed up to 2 months. Histological analysis revealed increased collagen deposition in 3-week old construct. This study opens a new venue of using favorable biomaterials for biofabricating tissue engineered vascular grafts that possess mechanical and biological properties comparable to small diameter human blood vessels.
Professor
Department Chair of Biomedical Engineering
Director of Center of Biomanufacturing for Regenerative Medicine
Binghamton University (BU), State University of New York (SUNY), United States
Biography:
Dr. Kaiming Ye is Professor and Department Chair of Biomedical Engineering and Director of Center of Biomanufacturing for Regenerative Medicine at the Binghamton University (BU), State University of New York (SUNY). He is one of the top most distinguished and accomplished leaders in the field of Medical and Biological Engineering. He is fellow of AIMBE and senior member of IEEE. His scholarly contributions to the field include the development of the concept of advanced biomanufacturing and his leadership role in promoting and growing the field. He co-organized more than 10 workshops, including two WTEC studies: one for global assessment of stem cell science and engineering and the other for global assessment of advanced biomanufacturing to promote and grow the field of advanced biomanufacturing, He is well known for his work in bioprinting and pancreatic organoid development. He has invented a tissue biofabrication platform tissue organoid development and fluorescent nanosensors for continuous glucose monitoring. His work in advanced biomanufacturing was featured as a cover story of ASEE PRISM journal. His work in glucose sensors was featured in the Pittsburgh Post-Gazette. His research has been continuously supported by NIH, NSF, JDRF, ABI and industries. He has chaired and co-chaired a number of international conferences and has delivered keynote/plenary speech in numerous international and national conferences. He is also a highly accomplished administrator and has contributed significantly to national policy-make in science and engineering. During his tenure at NSF, he directed a biomedical engineering program, making funding decisions and implementing post-award management. He was member of a number of interagency working groups, including the Interagency Workgroup for Neuroscience under the Office of Science and Technology Policy (OSTP), Interagency Modeling and Analysis Workgroup, and Multiagency Tissue Engineering and Regenerative Medicine Workgroup. In addition, he was involved in NSF CIF21 IGRET program, cyber-enabled science and engineering program, NIH/NSF joint program on interface between physics and life science, and NIH/NCI-NSF Physicals and Engineering Sciences in Oncology program. Finally, he is a highly accomplished educator in biomedical engineering. As chair of Biomedical Engineering Department at BU, he led the growth of the Department.
Abstract:
Bioinks for 3D Printing Tissue Engineered Vascular Grafts
3D bioprinting enables developing tissue constructs with heterogeneous compositions and complex structures. It has been adopted for printing multicellular tissues. Bioengineered vascular constructs have gained increased interest as a promising alternative to autologous vessel grafts. 3D printed vascular constructs promise to be a customizable, patient specific alternative but the question of whether to use synthetic or natural materials remains. In this work, we characterized an additive biomanufacturing method that allows the use of a soft biomaterial, fibrinogen, but enhances its printability to be compatible with extrusion bioprinting using a thermosreversible gelatin. With a 3D rotatory bioprinter developed in our lab, we demonstrated the feasibility of on-demand printing tissue engineered vascular grafts. We interrogated a number of biomaterials and developed a blend bioink that possesses essential rheological properties for rotatory bioprinting. We showed that the printed constructs increased in elastic modulus and ultimate tensile strength over time with viable cells observed up to 2 months. Histological analysis revealed increased collagen deposition in 3-week old construct. This study opens a new venue of using favorable biomaterials for biofabricating tissue engineered vascular grafts that possess mechanical and biological properties comparable to small diameter human blood vessels.