Ju Ji hyeon
Ji Hyeon Ju, M.D., Ph.D.
Division of Rheumatology,
Department of Internal Medicine,Medical college,
The Catholic University of Korea
Seoul St. Mary's Hospital
Telephone 82-2-2258-6911, Mobile 82-10-6472-3970
FAX 82-2-537-2274
E-mail juji@catholic.ac.kr
APPOINTMENTS
Mar. 2004 – Apr. 2005 Chief, Dept of Internal Medicine, Army Headquater Hospital, Kaeryongdae Army headquaters.
May. 2005 – Feb. 2007 Clinical Instructor, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
Mar. 2007 – Feb. 2011 Assistant Professor, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital
The Catholic University of Korea, Seoul, Korea
Mar. 2011 – Feb. 2014 Associate Professor, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital
The Catholic University of Korea, Seoul, Korea
Mar. 2012 – Jun. 2013 Visiting Scholar, Stanford University
Mar. 2015 – Present Professor, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Marys Hospital ,The Catholic University of Korea, Seoul, Korea
Abstract:
New strategy to repair osteoarthritic cartilage using injectable chondrosheroid
Regeneration of articular cartilage is of great interest in cartilage tissue engineering since the articular cartilage has low regenerative capacity. Due to the difficulty to obtain a healthy cartilage for transplantation, it is focused to develop an alternative and effective regeneration therapy to treat degenerative or damaged joint diseases. Stem cells including various adult stem cells and pluripotent stem cells are now actively used in tissue engineering. Several stem cell products come out in the market. These commercial products are made from mesenchymal stem cell or cultured chondrocyte. However, commercially available cell therapeutics revealed no direct regenerative effect on cartilage till now. Here, we developed a novel strategy using “spheroid-based”, “induced pluripotent stem cell-derived” and intra-articular injectable form. The novel therapy is effective for cartilage regeneration in rat, rabbit and beagle osteoarthritic models. Origin of regenerated cartilage tissue is proven to be human, which means this therapeutics play a direct role in cartilage regeneration.
Division of Rheumatology,
Department of Internal Medicine,Medical college,
The Catholic University of Korea
Seoul St. Mary's Hospital
Telephone 82-2-2258-6911, Mobile 82-10-6472-3970
FAX 82-2-537-2274
E-mail juji@catholic.ac.kr
APPOINTMENTS
Mar. 2004 – Apr. 2005 Chief, Dept of Internal Medicine, Army Headquater Hospital, Kaeryongdae Army headquaters.
May. 2005 – Feb. 2007 Clinical Instructor, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
Mar. 2007 – Feb. 2011 Assistant Professor, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital
The Catholic University of Korea, Seoul, Korea
Mar. 2011 – Feb. 2014 Associate Professor, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital
The Catholic University of Korea, Seoul, Korea
Mar. 2012 – Jun. 2013 Visiting Scholar, Stanford University
Mar. 2015 – Present Professor, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Marys Hospital ,The Catholic University of Korea, Seoul, Korea
Abstract:
New strategy to repair osteoarthritic cartilage using injectable chondrosheroid
Regeneration of articular cartilage is of great interest in cartilage tissue engineering since the articular cartilage has low regenerative capacity. Due to the difficulty to obtain a healthy cartilage for transplantation, it is focused to develop an alternative and effective regeneration therapy to treat degenerative or damaged joint diseases. Stem cells including various adult stem cells and pluripotent stem cells are now actively used in tissue engineering. Several stem cell products come out in the market. These commercial products are made from mesenchymal stem cell or cultured chondrocyte. However, commercially available cell therapeutics revealed no direct regenerative effect on cartilage till now. Here, we developed a novel strategy using “spheroid-based”, “induced pluripotent stem cell-derived” and intra-articular injectable form. The novel therapy is effective for cartilage regeneration in rat, rabbit and beagle osteoarthritic models. Origin of regenerated cartilage tissue is proven to be human, which means this therapeutics play a direct role in cartilage regeneration.